Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently release low-energy, short-range photoelectrons during external beam radiation therapy (RT), increasing the local radiation dose. When AuNPs are near tumor vasculature, the additional radiation dose can lead to increased vascular permeability. This work focuses on understanding how tumor vascular permeability is influenced by AuNP-augmented RT, and how this effect can be used to improve the delivery of nanoparticle chemotherapeutics.

中文翻译：

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金纳米粒子增强放射治疗后肿瘤脂质体递送的双能 CT 成像

金纳米粒子 (AuNPs) 正在成为癌症治疗和计算机断层扫描 (CT) 成像的有前途的药物。AuNPs 吸收 X 射线并随后在外束放射治疗 (RT) 期间释放低能量、短程光电子，从而增加局部辐射剂量。当 AuNPs 靠近肿瘤脉管系统时，额外的辐射剂量会导致血管通透性增加。这项工作的重点是了解肿瘤血管通透性如何受到 AuNP 增强 RT 的影响，以及如何利用这种效应来改善纳米颗粒化疗药物的递送。