Rationale: Cardiac stem cell-derived exosomes have been demonstrated to promote cardiac regeneration following myocardial infarction in preclinical studies. Recent studies have used intramyocardial injection in order to concentrate exosomes in the infarct. Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targeting peptide, cardiac homing peptide (CHP), to target intravenously-infused exosomes to the infarcted heart.

中文翻译：

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使用心脏归巢肽将再生外泌体靶向心肌梗死

理由：在临床前研究中，心脏干细胞来源的外泌体已被证明可以促进心肌梗死后的心脏再生。最近的研究使用心肌内注射来浓缩梗塞处的外泌体。虽然这种方法在研究环境中有效，但由于其侵入性，在临床上并不有吸引力。我们建议使用靶向肽——心脏归巢肽（CHP），将静脉输注的外泌体靶向梗塞心脏。