Cardiovascular diseases resulting from atherosclerosis have become a serious threat to human health. It is well-known that an ongoing inflammatory response is involved during atherosclerosis progression that ultimately results in the accumulation of lipids and formation of plaques. Monitoring the pathological changes during the inflammatory response will be of great significance for early diagnosis and therapeutic evaluation of atherosclerosis. Targeted contrast-enhanced ultrasonography has been shown to be a promising noninvasive imaging technique for evaluating the degree of atherosclerosis and may potentially be translated to clinical imaging in the future. However, inadequate cell adhesion of targeted microbubbles (MBs) in large arterial vessels still remains a great challenge.

中文翻译：

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超声分子成像的动脉粥样硬化，通过白细胞样多靶点微气泡的早期诊断和治疗评估。

由动脉粥样硬化引起的心血管疾病已成为对人类健康的严重威胁。众所周知，在动脉粥样硬化发展过程中涉及正在进行的炎症反应，最终导致脂质的积累和斑块的形成。监测炎症反应过程中的病理变化对动脉粥样硬化的早期诊断和治疗评估具有重要意义。靶向造影剂超声检查已被证明是用于评估动脉粥样硬化程度的一种有前途的无创成像技术，将来可能会转化为临床成像。然而，在大动脉血管中靶向微泡（MBs）的细胞粘附不足仍然是一个巨大的挑战。