Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems of low drug permeability and inherent or acquired drug resistance. Development of new strategies for enhanced therapy still remains a great challenge. Herein, we report a new ultrasound-targeted microbubble destruction (UTMD)-promoted delivery system based on dendrimer-entrapped gold nanoparticles (Au DENPs) for co-delivery of gemcitabine (Gem) and miR-21 inhibitor (miR-21i).

中文翻译：

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树枝状大分子包裹的金纳米粒子通过UTMD促进吉西他滨和miR-21抑制剂共同递送，用于胰腺癌治疗。

胰腺癌（PaCa）的常规化学疗法具有药物渗透性低和固有或获得的耐药性的问题。研发增强治疗的新策略仍然是一个巨大的挑战。在此，我们报告了一种新的超声靶向微泡破坏（UTMD）促进的递送系统，该系统基于树状聚合物包裹的金纳米颗粒（Au DENPs），用于共同递送吉西他滨（Gem）和miR-21抑制剂（miR-21i）。