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α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis
Theranostics ( IF 12.4 ) Pub Date : 2018-02-16 , DOI: 10.7150/thno.24385
Cheong-Yong Yun , Seon Mi Ko , Yong Pyo Choi , Beom Joon Kim , Jungno Lee , Jae Mun Kim , Ju Yeon Kim , Jin Yong Song , Song-Hee Kim , Bang Yeon Hwang , Jin Tae Hong , Sang-Bae Han , Youngsoo Kim

Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica.

中文翻译:

α-Viniferin通过促进兼性黑色素生成中cAMP / PKA信号化的磷酸化回路的反馈终止来改善面部色素沉着

原理: cAMP在色素沉着的黑素体生成过程中上调与小眼科相关的转录因子M亚型(MITF-M)和酪氨酸酶(Tyro)。在这里,我们通过锦鸡儿属的活性成分α-viniferin传达了色素沉着过度的治疗机制。
更新日期:2018-07-01
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