An asymmetric four‐component [5+1+1+1] formal cycloaddition reaction of 3‐substituted 2‐cyclopentenones, activated methylene nucleophiles and two molecules of aldehydes is developed under chiral primary aminocatalysis, producing a diversity of highly enantioenriched fused and spirocyclic frameworks with high molecular complexity. Mechanism studies indicate that the current reaction proceeds in a challenging cascade quintuple Knoevenagel condensation/Michael addition/retro‐Michael addition/Michael addition/Michael addition sequence via diverse aminocatalytic modes.

中文翻译：

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通过五重级联过程的有机催化不对称四组分[5 + 1 + 1 + 1]环加成反应

在手性伯氨基催化条件下，发生了由3-取代的2-环戊烯酮，活化的亚甲基亲核试剂和两个醛类分子组成的不对称四组分[5 + 1 + 1 + 1]正式环加成反应，产生了多种高度对映体富集的稠合和螺环骨架分子复杂性高。机理研究表明，当前的反应以具有挑战性的级联五元Knoevenagel缩合/ Michael加成/复古Michael加成/ Michael加成/ Michael加成序列通过多种氨基催化模式进行。