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Induction Heating Efficiency of Water-Dispersible Mn0.5Fe2.5O4@YVO4:Eu3+ Magnetic-Luminescent Nanocomposites in an Acceptable ac Magnetic Field: Hemocompatibility and Cytotoxicity Studies
The Journal of Physical Chemistry B ( IF 3.3 ) Pub Date : 2018-06-29 , DOI: 10.1021/acs.jpcb.8b02364
Goutam Singh Ningombam 1 , Raghumani Singh Ningthoujam 2 , Subbaraya Narayana Kalkura 3 , Nongmaithem Rajmuhon Singh 1
Affiliation  

Not many reports are available on magnetic-luminescent nanocomposites for cancer hyperthermia applications. Further, such nanocomposites on Mn2+-doped iron oxide may be available rather rarely. Studies on the induction heating properties within the threshold magnetic field and frequency factors are still rare. In most cases, magnetic nanoparticles are studied for hyperthermia and lanthanide-doped luminescent nanoparticles for certain biomedical applications. Here, we report on water-dispersible superparamagnetic manganese-doped iron oxide (Mn0.5Fe2.5O4) nanoparticles and a polyethylene glycol6000-coated magnetic-luminescent nanocomposite. The nanocomposite is composed of magnetic Mn0.5Fe2.5O4 (average size 10–20 nm) nanoparticles and red-emitting YVO4:Eu3+ (average size 40–50 nm) nanoparticles. These magnetic nanoparticles and nanocomposites are studied for their induction heating abilities at different acceptable Hf values (H, strength of alternating magnetic field and f, the operating frequency). The operational Hf values lie in the ranges of 2.15 × 106 to 4.58 × 106 kA m–1 s–1 that are well below the threshold limit of 5 × 106 kA m–1 s–1. A specific absorption rate as high as 132 and 63 W/g, respectively, for Mn0.5Fe2.5O4 and Mn0.5Fe2.5O4@YVO4:Eu3+, can be achieved. The rate of heating and the temperature achieved with time can be tuned with concentrations as well as magnetic constituents in the nanocomposites. Hemocompatibility analysis revealed high blood compatibility with <5% hemolysis. The cytotoxicity analysis in the MCF-7 cell line showed that the cell viability is 74–85% for 0.2–0.5 mg of the magnetic-luminescent nanocomposites. Beyond this concentration, the percentage of cell death is very high. The red-emitting magnetic-luminescent nanocomposites will be useful for in vitro optical imaging and tracking of magnetic nanoparticles. The magnetization analysis showed that the samples have high enough saturation magnetization and low residual magnetization, which is quite suitable for clinical applications. The water dispersibility, hemocompatibility, and cytotoxicity assay in conjunction with their efficient induction heating abilities have shown that these magnetic-luminescent nanocomposites will have potential applications in magnetic fluid hyperthermia and optical imaging.

中文翻译:

在可接受的交流磁场中水分散性Mn 0.5 Fe 2.5 O 4 @YVO 4:Eu 3+磁性发光纳米复合材料的感应加热效率:血液相容性和细胞毒性研究

关于用于癌症热疗应用的磁致发光纳米复合材料的报道并不多。此外,在Mn 2+掺杂的氧化铁上的这种纳米复合材料可能很少得到。在阈值磁场和频率因子范围内对感应加热特性的研究仍然很少。在大多数情况下,针对某些生物医学应用,研究了磁性纳米颗粒的热疗和镧系元素掺杂的发光纳米颗粒。在这里,我们报告水可分散的超顺磁性锰掺杂的氧化铁(Mn 0.5 Fe 2.5 O 4)纳米粒子和聚乙二醇6000涂层的磁致发光纳米复合材料。纳米复合材料由磁性Mn 0.5 Fe 2.5组成O 4(平均大小10–20 nm)纳米颗粒和发红光的YVO 4:Eu 3+(平均大小40–50 nm)纳米颗粒。研究了这些磁性纳米颗粒和纳米复合材料在不同的可接受Hf值(H,交变磁场强度和f,工作频率)下的感应加热能力。工作Hf值在2.15×10 6到4.58×10 6 kA m –1 s –1的范围内,远低于阈值极限5×10 6 kA m –1 s –1的范围。Mn 0.5 Fe 2.5 O 4和Mn 0.5 Fe 2.5 O 4 @YVO 4:Eu 3+的比吸收率分别高达132和63 W / g。, 可以实现。加热速率和随时间达到的温度可通过纳米复合物中的浓度以及磁性成分进行调整。血液相容性分析显示,血液溶出度低于5%时具有很高的血液相容性。MCF-7细胞系的细胞毒性分析表明,对于0.2-0.5 mg的磁致发光纳米复合材料,细胞活力为74-85%。超过该浓度,细胞死亡的百分比非常高。发出红色光的磁性发光纳米复合材料将用于磁性纳米粒子的体外光学成像和跟踪。磁化分析表明样品具有足够高的饱和磁化强度和低残留磁化强度,非常适合临床应用。水分散性,血液相容性,
更新日期:2018-06-30
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