Vitamin B₁₂, folic acid, and docosahexaenoic acid levels are reported to be altered in women with preeclampsia. This study examined the effect of the above nutrients on brain neurotrophins and on the cognitive performance in adult offspring in a pregnancy-induced hypertension rat model. Pregnant dams were assigned to control, PIH-induced, and PIH-induced supplemented with vitamin B₁₂, folate, omega-3 fatty acids, and the combined supplementation of vitamin B₁₂, folate, and omega-3 fatty acids groups. In the PIH group, brain-derived neurotrophic factor levels (BDNF) were lower in the offspring at birth, while the adult offspring showed lower levels of docosahexaenoic acid (DHA) in the hippocampus and BDNF (p < 0.05 for both) in the cortex as compared to in the control group. They also demonstrated higher (p < 0.05) escape latency in the Morris water maze test and performed a greater (p < 0.01 for all) number of errors in the Radial eight-arm maze test. A combined supplementation of vitamin B₁₂, folic acid, and omega-3 fatty acids improved the levels of LCPUFA, neurotrophins, and cognition. A maternal diet consisting of high levels of folate, vitamin B₁₂, and DHA reduced the risk for cognitive disorders in the adult offspring in an animal model of pregnancy-induced hypertension.

中文翻译：

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增加维生素B ₁₂，叶酸和omega-3脂肪酸的摄入量，以改善妊娠高血压大鼠出生后代的认知能力

据报道，先兆子痫妇女的维生素B ₁₂，叶酸和二十二碳六烯酸水平发生了变化。这项研究检查了上述营养素对妊娠高血压大鼠模型中脑神经营养蛋白和成年后代认知能力的影响。妊娠母鼠被分为对照组，PIH诱导和PIH诱导，补充维生素B ₁₂，叶酸，omega-3脂肪酸，以及维生素B ₁₂，叶酸和omega-3脂肪酸的组合补充。在PIH组中，出生后代的脑源性神经营养因子水平（BDNF）较低，而成年后代的海马和BDNF中二十二碳六烯酸（DHA）的水平较低（p与对照组相比，两者的皮层厚度均<0.05）。他们在莫里斯水迷宫测试中还表现出更高的逃逸潜伏期（p <0.05），并且在径向八臂迷宫测试中表现出了更大的错误率（所有p <0.01）。维生素B ₁₂，叶酸和omega-3脂肪酸的组合补充可以改善LCPUFA，神经营养蛋白和认知水平。在孕妇诱发的高血压动物模型中，由高含量的叶酸，维生素B ₁₂和DHA组成的孕妇饮食可降低成年后代认知障碍的风险。