The enantioselective synthesis of spirocycles has long been pursued by organic chemists. Despite their unique 3D properties and presence in several natural products, the difficulty in their enantioselective synthesis makes them underrepresented in pharmaceutical libraries. Since the first pioneering reports of the enantioselective construction of spirosilanes by Tamao et al., significant effort has been devoted towards the development of new promising asymmetric methodologies. Remarkably, with the advent of organocatalysis, particularly over six years, the reported methodologies for the synthesis of spirocycles have increased exponentially. The aim of this review is to summarize the latest trends and developments in the enantioselective synthesis of spirocompounds during these last six years.

中文翻译：

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螺环化合物的对映选择性合成的新进展†

有机化学家长期以来一直在追求螺环的对映选择性合成。尽管它们具有独特的3D特性并存在于几种天然产物中，但对映选择性合成的困难使它们在药物库中的代表性不足。自Tamao等人首次报道螺硅烷的对映选择性结构以来。，人们已经为开发新的有前途的非对称方法付出了巨大的努力。值得注意的是，随着有机催化的到来，尤其是六年来，已报道的螺环的合成方法已成倍增加。这篇综述的目的是总结过去六年来螺化合物的对映选择性合成的最新趋势和发展。