Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key signaling molecules that play an important role in the inflammation and progression of many diseases such as cardiovascular disease, especially atherosclerosis. ROS are in particular a significant factor in the development of rheumatoid arthritis and other autoimmune diseases such as allergies. In this study, novel Fe₃O₄/CeO₂ core–shell theranostic nanoparticles capable of reacting with ROS and of being detected by MRI were synthesized and thoroughly characterized. In vitro studies, such as measurement of cell uptake, magnetic resonance imaging, toxicity and ROS scavenging, were conducted. The results indicate that the novel Fe₃O₄/CeO₂ theranostic nanoparticles are effective for scavenging ROS and show excellent magnetic resonance (MR) imaging performance. These theranostic nanomaterials, therefore, show great potential for the treatment and diagnosis of ROS-related inflammatory diseases.

中文翻译：

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新型氧化铁-氧化铈核-壳纳米粒子可作为ROS相关炎症疾病的潜在治疗物质†

活性氧（ROS）和活性氮（RNS）是关键信号分子，在许多疾病（例如心血管疾病，尤其是动脉粥样硬化）的炎症和进展中起着重要作用。ROS特别是类风湿关节炎和其他自身免疫性疾病（如变态反应）发展的重要因素。在这项研究中，合成并彻底表征了能够与ROS反应并能被MRI检测的新颖的Fe ₃ O ₄ / CeO ₂核-壳治疗药物纳米颗粒。进行了体外研究，例如细胞摄取的测量，磁共振成像，毒性和ROS清除。结果表明，新型Fe ₃ O₄ / CeO ₂治疗用纳米粒子可有效清除ROS，并显示出出色的磁共振（MR）成像性能。因此，这些治疗纳米材料在治疗和诊断与ROS有关的炎性疾病方面显示出巨大的潜力。