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Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice
Journal of Food and Drug Analysis ( IF 3.6 ) Pub Date : 2018-10-01 , DOI: 10.1016/j.jfda.2018.05.008
Yuzuru Iizuka 1 , Hyounju Kim 1 , Satoshi Hirako 2 , Kanako Chiba 1 , Masahiro Wada 1 , Akiyo Matsumoto 1
Affiliation  

The elderly patients with type 2 diabetes suffer more adverse drug events than young adults due to pharmacokinetic and pharmacodynamic changes associated with aging. Reducing the risks of these medication-related problems are equally important for the clinical care of older type 2 diabetes patients. Pioglitazone is used for treating type 2 diabetes as an oral antidiabetic drug. Despite pioglitazone is used helpful insulin sensitizers, the accumulation of subcutaneous fat is considered a major adverse effect of pioglitazone therapy. We investigated to reduce the adverse effect of pioglitazone by combination with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in aged diabetic KK mice. The accumulation of subcutaneous fat associated with high-dose pioglitazone is reduced by fish oil, suppressing lipogenesis and stimulating fatty acid β-oxidation in the liver. Our data suggest that adding fish oil to low-dose pioglitazone results in antidiabetic efficacy similar to that of the high-dose without concomitant body weight gain.

中文翻译:

低剂量吡格列酮联合鱼油对老年 2 型糖尿病小鼠的益处

由于与衰老相关的药代动力学和药效学变化,老年 2 型糖尿病患者比年轻人遭受更多的药物不良事件。降低这些药物相关问题的风险对于老年 2 型糖尿病患者的临床护理同样重要。吡格列酮作为口服抗糖尿病药物用于治疗 2 型糖尿病。尽管吡格列酮被用作有用的胰岛素增敏剂,但皮下脂肪的积累被认为是吡格列酮治疗的主要不良反应。我们研究了通过与富含二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 的鱼油组合来减少吡格列酮对老年糖尿病 KK 小鼠的不利影响。鱼油可减少与大剂量吡格列酮相关的皮下脂肪堆积,抑制脂肪生成并刺激肝脏中的脂肪酸β-氧化。我们的数据表明,在低剂量吡格列酮中添加鱼油可产生与高剂量相似的抗糖尿病功效,而不会伴随体重增加。
更新日期:2018-10-01
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