Biochimie ( IF 3.9 ) Pub Date : 2018-06-28 , DOI: 10.1016/j.biochi.2018.06.019 Rute S. Araújo , Daniela F. Santos , Gabriela A. Silva
Secreted trophic factors are key to maintain the structural and functional integrity of the retina, as they regulate cellular pathways responsible for survival, function, and response to injury. Nevertheless, these same factors can also be involved in retinal pathologies, as a consequence of the impairment of the secretory function of cells. The cells considered as major contributors to the retinal secretome are the retinal pigmented epithelium (RPE) and Müller cells. Their role in the pathophysiology of the most common neovascular pathologies in the retina - Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), and Retinopathy of Prematurity (ROP) - is highlighted in this short review, together with current trophic factor-based therapies, which are mainly focused on controlling inflammation, cell survival, and angiogenesis.
中文翻译:
视网膜色素上皮和Müller细胞分泌组在新生血管视网膜病理中的作用
分泌的营养因子是维持视网膜结构和功能完整性的关键,因为它们调节负责生存,功能和对损伤的反应的细胞途径。然而,由于细胞分泌功能的损害,这些相同的因素也可能涉及视网膜病理。视网膜色素上皮细胞(RPE)和Müller细胞被认为是视网膜分泌蛋白的主要成分。在这篇简短的综述中,重点介绍了它们在视网膜中最常见的新生血管病理(年龄相关性黄斑变性(AMD),糖尿病性视网膜病变(DR)和早产儿视网膜病变(ROP))的病理生理中的作用以及目前的营养因子。疗法,主要集中在控制炎症,细胞存活和血管生成。