The adulteration of whiskey with analgesics and sedation drugs has been a common practice to prevent hangover the following day and promote loss of consciousness. In both situations, the portable and low cost detection platforms are of paramount importance for forensic investigations. This report describes the use of electrochemical paper‐based analytical devices (ePADs) fabricated by pencil drawing for detecting metamizole, paracetamol and midazolam maleate in whiskey. Different types of paper substrates and graphite pencils were initially characterized with ferrocyanide. The best results were achieved using vegetal paper and Aquarelle/6B pencils. ePADs revealed a decrease in current signal indicating a short lifetime, thus limiting their use to disposable sensors. Despite the short lifetime, the graphite pencil ePADs revealed good electrochemical reproducibility (RSD=3.3 %). The forensic feasibility of the proposed ePADs was demonstrated through the analysis of metamizole and paracetamol in whiskey. The limit of detection (LOD) achieved for paracetamol and metamizole were 45 and 20 mg L⁻¹, respectively. ePADs were also tested to detect midazolam maleate in whiskey. The signal recorded exhibited linear correlation in a wide concentration range (25–1000 mg L⁻¹) and a LOD of ca. 5 mg L⁻¹. Considering the disposability and operational simplicity, ePADs offer a good strategy for detecting adulterations in alcoholic beverages at the point‐of‐need.

中文翻译：

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使用基于电化学纸的分析设​​备检测威士忌中的镇痛药和镇静药

威士忌与镇痛药和镇静药一起掺假是防止第二天宿醉并促进意识丧失的一种普遍做法。在两种情况下，便携式和低成本检测平台对于法医调查都至关重要。本报告介绍了通过铅笔素描制造的基于电化学纸的分析设​​备（ePAD）在威士忌中检测间苯二酚，扑热息痛和马来酸咪达唑仑的方法。最初使用亚铁氰化物对不同类型的纸张基材和石墨铅笔进行了表征。使用植物纸和Aquarelle / 6B铅笔可达到最佳效果。ePAD显示电流信号减小，表明使用寿命很短，因此将其用于一次性传感器。尽管寿命短，石墨笔ePAD显示出良好的电化学重现性（RSD = 3.3％）。通过分析威士忌中的间苯二酚和扑热息痛证明了拟议的ePAD的法证可行性。扑热息痛和扑热息痛的检出限（LOD）为45和20 mg L^-1。还对ePAD进行了检测，以检测威士忌中的马来酸咪达唑仑。所记录的信号在较宽的浓度范围（25–1000 mg L ^-1）内表现出线性相关性，LOD约为ca。5 mg L ^-1。考虑到可处置性和操作简便性，ePAD提供了一种在需要时检测酒精饮料中掺假的好策略。