A β-arylation of primary sp³C–H bonds on simple amides such as pivalamides with aryl iodides/CF₃CO₂Ag has been established successfully at 120 °C in a Pd(OAc)₂ (catalyst)/CF₃CH₂OH (solvent) system. Pivalamides including ^tBuCONH₂, ^tBuCONHR, and ^tBuCONR₂ undergo the arylations smoothly to afford β-aryl pivalamides in moderate to good yields. Various aryl iodides are available bearing either electron-donating or electron-withdrawing substituted groups in the coupling reactions.

中文翻译：

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钯通过主sp ³ C–H活化催化酰胺的β-芳基化

在120°C的Pd（OAc）₂（催化剂）/ CF ₃ CH _2中成功建立了简单酰胺（如新戊酰胺）上的初生sp ³ C–H键与芳基碘化物/ CF ₃ CO ₂ Ag的β-芳基化作用。OH（溶剂）体系。包括^t BuCONH ₂，^t BuCONHR和^t BuCONR ₂在内的新戊酰胺平稳地进行芳基化反应，以中等至良好的收率得到β-芳基新戊酰胺。可获得各种在偶联反应中带有给电子或吸电子取代基的芳基碘化物。