Degradable electronics represent a rapidly emerging field of science and technology with the potential to serve short‐term medical implantation applications where the device disappears once its function is complete. Despite many efforts in developing new types of degradable electronics, many of such systems are nonelastic and incompatible with the dynamic motion of native soft/elastic biological tissues. Herein, a photo‐crosslinkable hydrogel with integrated electronics that are highly stretchable and degradable in liquid environments is demonstrated. The fabrication process takes advantage of facile laser micromachining of conductive patterns directly onto the hydrogel under ambient conditions and permanent hydrogel–hydrogel bonding. The robustness and degradation rate of hydrogel and the laser‐processed encapsulated stretchable circuits is systematically investigated in different solutions under various conditions. Biocompatibility tests with non‐neoplastic cells (HMT 3522 S1) and cancer cells (T4‐2 and MDA‐MB‐231) are performed in 2D and 3D cell culture systems to confirm instead of evaluate the safety of the hydrogel and its byproducts during degradation as well as the zinc metal used in this technology. As a proof of concept, a stretchable hydrogel‐based device that can be used for remote/wireless delivery of thermal energy into the tissue in contact with the hydrogel is fabricated.

中文翻译：

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在可水解降解的水凝胶上对可拉伸电子进行激光处理

可降解电子器件代表了一个迅速发展的科学技术领域，具有为短期医疗植入应用服务的潜力，一旦该设备功能完成，该设备便会消失。尽管在开发新型可降解电子装置方面进行了许多努力，但是许多这样的系统是非弹性的并且与天然软/弹性生物组织的动态运动不兼容。本文中，展示了具有集成电子器件的可光交联水凝胶，该电子器件在液体环境中具有高度可拉伸性和降解性。制造过程利用了在环境条件下将导电图案直接激光激光微加工到水凝胶上以及永久性的水凝胶-水凝胶键合的优势。在各种条件下，在不同的解决方案中，系统地研究了水凝胶和激光处理的封装可拉伸电路的鲁棒性和降解率。在2D和3D细胞培养系统中对非肿瘤细胞（HMT 3522 S1）和癌细胞（T4-2和MDA-MB‐231）进行生物相容性测试，以确认而不是评估降解过程中水凝胶及其副产物的安全性以及该技术中使用的锌金属。作为概念验证，制造了一种可拉伸的基于水凝胶的设备，该设备可用于将热能远程/无线传输到与水凝胶接触的组织中。在2D和3D细胞培养系统中对非肿瘤细胞（HMT 3522 S1）和癌细胞（T4-2和MDA-MB‐231）进行生物相容性测试，以确认而不是评估降解过程中水凝胶及其副产物的安全性以及该技术中使用的锌金属。作为概念验证，制造了一种可拉伸的基于水凝胶的设备，该设备可用于将热能远程/无线传输到与水凝胶接触的组织中。在2D和3D细胞培养系统中对非肿瘤细胞（HMT 3522 S1）和癌细胞（T4-2和MDA-MB‐231）进行生物相容性测试，以确认而不是评估降解过程中水凝胶及其副产物的安全性以及该技术中使用的锌金属。作为概念验证，制造了一种可拉伸的基于水凝胶的设备，该设备可用于将热能远程/无线传输到与水凝胶接触的组织中。