The need for point-of-care devices able to detect diseases early and monitor their status, out of a lab environment, has stimulated the development of compact biosensing configurations. Whereas localized surface plasmon resonance (LSPR) sensing integrated into a state-of-the-art microfluidic chip stands as a promising approach to meet this demand, its implementation into an operating sensing platform capable of quantitatively detecting a set of molecular biomarkers in an unknown biological sample is only in its infancy. Here, we present an on-chip LSPR sensor capable of performing automatic, quantitative, and multiplexed screening of biomarkers. We demonstrate its versatility by programming it to detect and quantify in human serum four relevant human serum protein markers associated with breast cancer.

中文翻译：

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自校准片上局部表面等离子共振感应定量和多重检测人血清中的癌症标志物。

对需要能够在实验室环境之外及早发现疾病并监测疾病状态的即时医疗设备的需求刺激了紧凑型生物传感配置的发展。集成到最新的微流控芯片中的局部表面等离振子共振（LSPR）传感是满足此需求的一种有前途的方法，而将其实施到能够定量检测未知分子中的一组分子生物标志物的运行传感平台中生物样品仅处于婴儿期。在这里，我们介绍了一种片上LSPR传感器，该传感器能够执行生物标志物的自动，定量和多重筛选。我们通过对它进行编程以检测和定量与乳腺癌相关的四个相关人血清蛋白标志物来证明其多功能性。