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Lewis acid-mediated mono- and bis-addition of C-nucleophiles to 1,3-dioxolan-4-ones
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2018-06-28 , DOI: 10.1016/j.tetlet.2018.06.060
Vitaly A. Shcherbinin , Valery V. Konshin

The reactions of 1,3-dioxolan-4-ones, readily available from α-hydroxy acids and aldehydes, with C-nucleophiles are described. Two possible reaction pathways resulting in O-substituted acids and tri-(hetero)arylmethanes are shown.



中文翻译:

Lewis酸介导的C-亲核试剂单加双加成到1,3-二氧戊环4-ones

描述了可容易地从α-羟基酸和醛获得的1,3-二氧戊环-4-酮与C-亲核试剂的反应。显示了导致O-取代的酸和三(杂)芳基甲烷的两种可能的反应途径。

更新日期:2018-06-28
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