Economic games —trust (TG) and ultimatum game (UG)— combined with fMRI have shown the importance of the anterior insula (AI) in social normative behaviors. However, whether different AI subregions are engaged in different cognitive and affective processes for social norm compliance and norm enforcement during social exchange remains elusive. Here, we investigated the role of the dorsal AI (dAI) and ventral AI (vAI), combining a coordinate-based meta-analysis of fMRI studies using the TG and UG with meta-analytic task-based and task-free connectivity analyses. Our findings showed that the right dAI and vAI were the only common brain regions consistently activated across games. These clusters were part of two functionally distinguishable connectivity networks associated with cognitive (dAI) and emotional (vAI) processes. In conclusion, we propose that dAI mediates cognitive processes that generate expectancy for norm compliance, whereas vAI mediates aversive feelings that generate motivation to norm enforcement. The identified functional differentiation of the right AI in the social domain contributes to a better understanding of its role in basic and clinical neuroscience.

经济博弈-信任（TG）和最后通game博弈（UG）-与fMRI结合显示了前岛绝缘（AI）在社会规范行为中的重要性。然而，在社会交往过程中，不同的AI子区域是否参与了不同的认知和情感过程，以实现社会规范的遵守和规范的执行。在这里，我们结合使用基于TG和UG的功能磁共振成像研究的基于坐标的荟萃分析以及基于任务和无任务的荟萃分析，研究了背侧AI（dAI）和腹侧AI（vAI）的作用。我们的研究结果表明，正确的dAI和vAI是整个游戏中唯一持续激活的常见大脑区域。这些集群是与认知（dAI）和情感（vAI）过程相关的两个功能上可区分的连通性网络的一部分。综上所述，我们建议dAI介导认知过程，从而产生对规范遵从性的期望，而vAI介导令人厌恶的情感，从而产生对规范执行的动机。正确的AI在社交领域的功能差异已被确定，有助于更好地了解其在基础和临床神经科学中的作用。