The cover feature picture shows the colorful mutasynthesis story of the production machinery for cyclic prodiginines in Pseudomonas putida KT2440. Pyrrole derivatives are supplemented to the fermentation broth and incorporated by a genetically modified P. putida strain. After the assembly of the highly bioactive prodiginines in P. putida, the natural product analogues are adsorbed by small polyurethane foam cubes, which can be easily fished out of the fermentation broth by the scientist. More information can be found in the full paper by J. Pietruszka et al. on page 1545 in Issue 14, 2018 (DOI: 10.1002/cbic.201800154).

中文翻译：

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封面人物：恶臭假单胞菌KT2440中的突变合成环糊精（ChemBioChem 14/2018）

封面特征图片显示了恶臭假单胞菌KT2440的循环蛋白质的生产机械的多彩突变过程。将吡咯衍生物添加到发酵液中，并通过基因修饰的恶臭假单胞菌菌株掺入。在恶臭假单胞菌中组装了具有高生物活性的蛋白质原粉后，天然产物类似物被小的聚氨酯泡沫塑料块吸附，科学家可以很容易地将其从发酵液中捞出。可以在J. Pietruszka等人的全文中找到更多信息。关于在第14期，2018页1545（：10.1002 / cbic.201800154 DOI）。