The public view on antibiotics as reliable medicines changed when reports about “resistant superbugs” appeared in the news. While reasons for this resistance development are easily spotted, solutions for re‐establishing effective antibiotics are still in their infancy. This Review encompasses several aspects of the antibiotic development pipeline from very early strategies to mature drugs. An interdisciplinary overview is given of methods suitable for mining novel antibiotics and strategies discussed to unravel their modes of action. Select examples of antibiotics recently identified by using these platforms not only illustrate the efficiency of these measures, but also highlight promising clinical candidates with therapeutic potential. Furthermore, the concept of molecules that disarm pathogens by addressing gatekeepers of virulence will be covered. The Review concludes with an evaluation of antibacterials currently in clinical development. Overall, this Review aims to connect select innovative antimicrobial approaches to stimulate interdisciplinary partnerships between chemists from academia and industry.

中文翻译：

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跳出思维定式—新颖的抗生素解决耐药性危机

当新闻中出现有关“抗性超级细菌”的报道时，公众对抗生素作为可靠药物的看法发生了变化。尽管很容易发现产生这种抗药性的原因，但重建有效抗生素的解决方案仍处于起步阶段。这篇综述涵盖了从很早的策略到成熟药物的抗生素开发流程的多个方面。跨学科概述了适合于开发新型抗生素的方法，并讨论了阐明其作用方式的策略。最近通过使用这些平台鉴定出的抗生素实例不仅说明了这些措施的有效性，而且突出了具有治疗潜力的有前途的临床候选药物。此外，将介绍通过解决毒力守卫者来解除病原体武装的分子概念。该综述以目前临床开发中的抗菌药物评估为结尾。总的来说，本综述旨在将创新的抗菌方法联系起来，以激发学术界和工业界化学家之间的跨学科合作关系。