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Cancer Metabolism: Current Understanding and Therapies
Chemical Reviews ( IF 62.1 ) Pub Date : 2018-06-25 00:00:00 , DOI: 10.1021/acs.chemrev.7b00775
Jessica L. Counihan 1 , Elizabeth A. Grossman 1 , Daniel K. Nomura 1
Affiliation  

Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and malignancy. This review also discusses various pharmacological manipulations that take advantage of these metabolic abnormalities and the current targeted therapies that have arisen from this research.

中文翻译:

癌症代谢:当前的认识和治疗

癌细胞新陈代谢的失调导致异常的细胞生长,这是癌症的生物学终点。我们在这里回顾了许多常见于癌症中的受影响癌基因和代谢途径,以及它们如何促成癌症的发病机理和恶性肿瘤。这篇综述还讨论了利用这些代谢异常的各种药理操作,以及该研究产生的当前靶向疗法。
更新日期:2018-06-25
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