A t-BuONa-mediated C–OH/P(O)–H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)–H compounds as the starting materials, providing an efficient alternative method for constructing sp³ C–P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.

中文翻译：

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直接C–OH / P（O）–H脱水偶联形成氧化膦†

开发了一种由t -BuONa介导的C-OH / P（O）-H交叉脱水偶联生成烷基膦氧化物的方法。该反应采用现成的醇和P（O）-H化合物作为起始原料，为构建sp ³ C-P键提供了一种有效的替代方法。提出了一个合理的反应路径，涉及到脱水和随后的烯烃选择性区域磷酸化。