Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009). The Psychiatric Ratings using Intermediate Stratified Markers (PRISM) project focusses on the shared and unique neurobiological basis of social withdrawal in schizophrenia, Alzheimer and depression. In this paper, we discuss the working definition of social withdrawal for this study and the selection of objective and subjective rating scales to assess social withdrawal chosen or adapted for this project. We also discuss the MRI and EEG paradigms selected to study the systems and neural circuitry thought to underlie social functioning and more particularly to be involved in social withdrawal in humans, such as the social perception and the social affiliation networks. A number of behavioral paradigms were selected to assess complementary aspects of social cognition. Also, a digital phenotyping method (a smartphone application) was chosen to obtain real-life data.

在许多重要的神经精神疾病中，社交退缩是早期社交功能障碍的最初且常见的征兆之一，这可能是由于发起和维持社交关系所需的大脑过程的数量巨大且复杂（Adolphs，2009）。使用中级分层标记的精神病学评分（PRISM）项目侧重于精神分裂症，阿尔茨海默氏症和抑郁症中社交退缩的共享且独特的神经生物学基础。在本文中，我们讨论了这项研究的社会退缩的工作定义，以及选择客观和主观等级量表以评估为该项目选择或调整的社会退缩。我们还将讨论MRI和EEG范例，这些范例被选择用于研究被认为是社会功能基础的系统和神经回路，尤其是涉及人类社交退缩的系统，例如社交知觉和社交网络。选择了许多行为范式来评估社会认知的互补方面。此外，选择了数字表型方法（智能手机应用程序）来获取现实生活中的数据。