A Cu-catalyzed regioselective bromodifluoroacetylation of alkenes, using ethyl bromodifluoroacetate (BrCF₂CO₂Et) as a difluoroacetylating reagent, has been disclosed. The reaction proceeds under mild conditions, and possible byproducts generated from hydrodifluoroacetylation and/or direct alkenyl C–H difluoroacetylation are not observed. Mechanistic studies confirm that the atom transfer radical addition (ATRA) process is involved in this alkene difunctionalization reaction.

中文翻译：

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铜催化的溴代二氟乙酸乙酯对烯烃的铜催化溴代二氟乙酰化

已经公开了使用溴二氟乙酸乙酯（BrCF ₂ CO ₂ Et）作为二氟乙酰化试剂的Cu催化的烯烃的区域选择性溴二氟乙酰化。该反应在温和的条件下进行，未观察到氢二氟乙酰化和/或直接烯基CH二氟乙酰化产生的副产物。机理研究证实，该烯烃双官能化反应涉及原子转移自由基加成（ATRA）过程。