The use of nanometer-sized semiconductor crystals, known as quantum dots, allows us to directly observe individual biomolecular transactions through a fluorescence microscope. Here, we review the evolution of single quantum dot tracking over the past two decades, highlight key biophysical discoveries facilitated by quantum dots, briefly discuss biochemical and optical implementation strategies for a single quantum dot tracking experiment, and report recent accomplishments of our group at the interface of molecular neuroscience and nanoscience.

中文翻译：

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单量子点追踪照亮了纳米尺度的神经科学

使用纳米尺寸的半导体晶体（称为量子点）使我们能够通过荧光显微镜直接观察单个生物分子的变化。在这里，我们回顾了过去二十年单量子点跟踪的演变，重点介绍了量子点促进的关键生物物理发现，简要讨论了单量子点跟踪实验的生化和光学实​​施策略，并报告了我们小组在分子神经科学和纳米科学的界面。