DNA repair inhibitors have broad clinical applications in tumor types with DNA repair defects, including colorectal cancer (CRC). Structural analogs of the anticancer agent sulforaphane (SFN) were investigated as modifiers of histone deacetylase (HDAC) and histone acetyltransferase (HAT) activity, and for effects on DNA damage/repair pertinent to human CRC.

中文翻译：

---

萝卜硫烷的杂环类似物触发结肠癌细胞中的DNA损伤并阻碍DNA修复：HAT和HDAC的相互作用

DNA修复抑制剂在具有DNA修复缺陷的肿瘤类型中具有广泛的临床应用，包括结肠直肠癌（CRC）。研究了抗癌药萝卜硫烷（SFN）的结构类似物，作为组蛋白脱乙酰基酶（HDAC）和组蛋白乙酰基转移酶（HAT）活性的修饰剂，以及对与人类CRC相关的DNA损伤/修复的影响。