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Involvement of CD8+ T cell subsets in early response to vascular injury in patients with peripheral artery disease in vivo
Clinical Immunology ( IF 8.6 ) Pub Date : 2018-06-21 , DOI: 10.1016/j.clim.2018.06.006
Pawel Maga 1 , Tomasz P Mikolajczyk 2 , Lukasz Partyka 3 , Mateusz Siedlinski 4 , Mikolaj Maga 5 , Marek Krzanowski 3 , Krzysztof Malinowski 6 , Kevin Luc 4 , Rafal Nizankowski 5 , Deepak L Bhatt 7 , Tomasz J Guzik 8
Affiliation  

Aims

Adaptive immunity is critical in vascular remodelling following arterial injury. We hypothesized that acute changes in T cells at a percutaneous transluminal angioplasty (PTA) site could serve as an index of their potential interaction with the injured vascular wall.

Methods and Results

T cell subsets were characterised in 45 patients with Rutherford 3–4 peripheral artery disease (PAD) undergoing PTA. Direct angioplasty catheter blood sampling was performed before and immediately after the procedure. PTA was associated with an acute reduction of α/β-TcR CD8+ T cells. Further characterisation revealed significant reduction in pro-atherosclerotic CD28nullCD57+ T cells, effector (CD45RA+CCR7-) and effector memory (CD45RA-CCR7-) cells, in addition to cells bearing activation (CD69, CD38) and tissue homing/adhesion markers (CD38, CCR5).

Conclusions

The acute reduction observed here is likely due to the adhesion of cells to the injured vascular wall, suggesting that immunosenescent, activated effector CD8+ cells have a role in the early vascular injury immune response following PTA in PAD patients.



中文翻译:

CD8+ T 细胞亚群参与体内外周动脉疾病患者血管损伤的早期反应

目标

适应性免疫对动脉损伤后的血管重塑至关重要。我们假设经皮腔内血管成形术 (PTA) 部位 T 细胞的急性变化可以作为它们与受损血管壁潜在相互作用的指标。

方法和结果

T 细胞亚群在 45 名接受 PTA 的卢瑟福 3-4 型外周动脉疾病 (PAD) 患者中进行了表征。在手术前和手术后立即进行直接血管成形术导管血液取样。PTA 与 α/β-TcR CD8+ T 细胞的急剧减少有关。进一步的表征显示,除了具有活化作用的细胞(CD69、CD38)和组织归巢/粘附标记物(CD38 , CCR5)。

结论

这里观察到的急性减少可能是由于细胞粘附到受伤的血管壁上,这表明免疫衰老、活化的效应 CD8+ 细胞在 PAD 患者 PTA 后的早期血管损伤免疫反应中起作用。

更新日期:2018-06-21
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