Mitochondria play a key role in a variety of physiological processes, and mitochondria-targeting drug delivery is helpful and effective in cancer therapy. Rhodamine123 (Rhod123) and Doxorubicin (Dox) are not new chemical molecules, and they both can inhibit the growth of cancerous cells. Here, we combine these two “old” chemicals with polydopamine nanoparticles (PDA NPs) to strengthen the antitumor effect with the aid of near-infrared irradiation. PDA NPs carry these two chemicals tightly by hydrogen bonds and π–π stacking besides chemical bonds. The better antitumor profile of PDA-Rhod-Dox comes from the mitochondria-targeting delivery, which decreases ATP in living cells, causing apoptosis of cancerous cells effectively and inhibiting the growth of tumors in mice. The synergistic effect of PDA, Rhod123, and Dox improves the treatment effect of conventional chemotherapy drugs.

中文翻译：

---

线粒体靶向聚多巴胺纳米复合材料作为癌症的化学光热疗法。

线粒体在多种生理过程中起着关键作用，而线粒体靶向药物的递送在癌症治疗中是有帮助和有效的。罗丹明123（Rhod123）和阿霉素（Dox）不是新的化学分子，它们都可以抑制癌细胞的生长。在这里，我们将这两种“老”化学物质与聚多巴胺纳米颗粒（PDA NPs）结合在一起，以借助近红外辐射增强抗肿瘤作用。PDA NP通过氢键和除化学键外的π-π堆积紧密地携带这两种化学物质。PDA-Rhod-Dox更好的抗肿瘤特性来自线粒体靶向递送，这降低了活细胞中的ATP，有效地导致了癌细胞的凋亡并抑制了小鼠肿瘤的生长。PDA，Rhod123，