Purpose

To evaluate the ability of OCT optic nerve head (ONH) and macular parameters to detect disease progression in eyes with advanced structural glaucomatous damage of the circumpapillary retinal nerve fiber layer (cRNFL).

Design

Longitudinal study.

Participants

Forty-four eyes from 37 patients with advanced average cRNFL damage (≤60 μm) followed up for an average of 4.0 years.

Methods

All patients were examined with spectral-domain OCT and visual field (VF) assessment during at least 4 visits.

Main Outcome Measurements

Visual field mean deviation (MD) and VF index. OCT cRNFL (average, superior, and inferior quadrants), ganglion cell–inner plexiform layer (GCIPL) (average, superior, and inferior), rim area, cup volume, average cup-to-disc (C:D) ratio, and vertical C:D ratio.

Results

At baseline, patients had a median VF MD of –10.18 dB and mean cRNFL of 54.55±3.42 μm. The rate of change for MD and VF index were significant. No significant rate of change was noted for cRNFL, whereas significant (P < 0.001) rates were detected for GCIPL (–0.57±0.05 μm/year) and ONH parameters such as rim area (–0.010±0.001 mm²/year).

Conclusions

Macula GCIPL and ONH parameters may be useful in tracking progression in patients with advanced glaucoma.

中文翻译：

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黄斑和视神经头参数能否检测到患有高级乳头状视网膜神经纤维层损伤的眼睛的青光眼进展？

目的

评估OCT视神经乳头（ONH）和黄斑参数检测具有高度结构性青光眼性眼眶乳头视网膜神经纤维层（cRNFL）的眼睛中疾病进展的能力。

设计

纵向研究。

参加者

来自37例平均cRNFL损害晚期（≤60μm）的患者的四十四只眼平均随访4.0年。

方法

在至少4次就诊期间，所有患者均接受了频谱域OCT和视野（VF）评估。

主要指标

视野平均偏差（MD）和VF指数。OCT cRNFL（平均，上，下象限），神经节细胞-内部丛状层（GCIPL）（平均，上，下），轮辋面积，杯体积，平均杯碟比（C：D）和垂直C：D比。

结果

基线时，患者的VF MD中位数为–10.18 dB，平均cRNFL为54.55±3.42μm。MD和VF指数的变化率是显着的。对于cRNFL，未发现明显的变化率，而对于GCIPL（–0.57±0.05μm/年）和ONH参数（如边缘区域）（– 0.010±0.001 mm ² /年），检测到显着（P <0.001）率。

结论

黄斑GCIPL和ONH参数可能有助于追踪晚期青光眼患者的进展。