By direct use of toluene derivatives as benzylation reagents and of CuCl as catalyst, 1,1‐disubstituted N‐acyl tetrahydroisoquinolines were prepared by radical addition and cyclization of N‐phenethyl enamides in moderate to good yields.

中文翻译：

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级联自由基加成和环化反应由酰胺类化合物合成1,1-二取代的N-酰基四氢异喹啉

通过直接使用甲苯衍生物作为苄基化试剂，并使用CuCl作为催化剂，通过对N-苯乙基酰胺进行自由基加成和环化反应，制备了1,1-二取代的N-酰基四氢异喹啉，产率中等至良好。