Multidrug resistance (MDR) is one of the most important reasons for the failure of clinical chemotherapy treatment of cancer patients. Although several strategies have been proposed to overcome MDR, their contributions in improving therapeutic efficacy are not adequate. Herein, we constructed a nano-twindrug using a supramolecular self-assembling strategy, with the aim of efficiently reversing MDR. Due to the supramolecular interactions, doxorubicin (DOX) and vorinostat (SAHA) could self-assemble into stable spherical nanoparticles with a size of ∼160 nm. Since the antitumor drugs were not modified by nontherapeutic drug carriers, our strategy ensured a drug-loading efficacy of 100%. Furthermore, our study revealed that the DOX-SAHA nano-twin drug could enter drug-resistant cancer cells and inhibit their proliferation more effectively in vitro than single DOX, SAHA, or a DOX/SAHA mixture. In the meantime, the DOX-SAHA nano-twin drug could accumulate at the tumor site in vivo and show higher antitumor efficacy accompanied by low side effects.

中文翻译：

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超分子自组装纳米双胞胎药物，可逆转多药耐药性†

多药耐药性（MDR）是临床化学疗法治疗癌症患者失败的最重要原因之一。尽管已经提出了克服MDR的几种策略，但是它们在提高治疗功效方面的贡献还不够。在本文中，我们使用超分子自组装策略构建了纳米车尾，目的是有效地逆转MDR。由于超分子相互作用，阿霉素（DOX）和伏立诺他（SAHA）可以自组装成尺寸约为160 nm的稳定球形纳米颗粒。由于非治疗药物载体未修饰抗肿瘤药物，因此我们的策略可确保100％的载药效率。此外，我们的研究表明，DOX-SAHA纳米双胞胎药物可以进入耐药性癌细胞并更有效地抑制其增殖。体外比单个DOX，SAHA或DOX / SAHA混合物要好。同时，DOX-SAHA纳米双胞胎药物可在体内肿瘤部位蓄积，显示出较高的抗肿瘤功效，同时副作用低。