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Serotonin and human cancer: A critical view
Biochimie ( IF 3.9 ) Pub Date : 2018-06-21 , DOI: 10.1016/j.biochi.2018.06.016
Denis Sarrouilhe , Marc Mesnil

Besides its classical functions as a neurotransmitter in the central nervous system, local mediator in the gastrointestinal tract and vasoactive agent in the blood, serotonin has more recently emerged as a growth factor for human tumor cells of different origins (carcinomas, glioma and carcinoids). Several data are also available on serotonin involvement in cancer cell migration, metastatic dissemination and tumor angiogenesis. The serotonin-induced signaling pathways that promote tumor progression are complex and only partly understood in some cancer types. The results of several studies showed that serotonin levels in the tumor played a crucial role in cancer progression. A serotonin production and secretion by neuroendocrine cells have been shown in the progression of several solid tumors and the involvement of a serotoninergic autocrine loop was proposed. Specific receptor subtypes are associated with different fundamental stages of tumor progression and the pattern of receptors expression becomes dysregulated in several human tumors when compared with normal cells or tissues. Serotonin receptors, selective serotonin transporter and serotonin synthesis pathways are potential chemotherapeutic targets for the treatment of several cancers in which therapeutic approaches are limited. Through several asked questions, this critical mini-review discusses the relevance of the involvement of serotonin in human cancer progression.



中文翻译:

5-羟色胺与人类癌症:批判性观点

除了其在中枢神经系统中作为神经递质的经典功能,在胃肠道中的局部介体和血液中的血管活性剂外,5-羟色胺最近已成为不同来源的人类肿瘤细胞(癌,神经胶质瘤和类癌)的生长因子。关于血清素参与癌细胞迁移,转移性传播和肿瘤血管生成的一些数据也可得到。血清素诱导的促进肿瘤进展的信号通路是复杂的,在某些癌症类型中仅部分被理解。几项研究的结果表明,肿瘤中的血清素水平在癌症进展中起着至关重要的作用。在一些实体瘤的进展中已经显示出神经内分泌细胞产生5-羟色胺和分泌,并提出了5-羟色胺能自分泌环的参与。与正常细胞或组织相比,特定受体亚型与肿瘤进展的不同基本阶段有关,并且在几种人类肿瘤中受体表达的模式变得失调。5-羟色胺受体,选择性5-羟色胺转运蛋白和5-羟色胺合成途径是潜在的化学治疗靶标,用于治疗治疗方法受限的几种癌症。通过一些常见问题,这项重要的小型回顾讨论了血清素参与人类癌症进展的相关性。与正常细胞或组织相比,特定受体亚型与肿瘤进展的不同基本阶段有关,并且在几种人类肿瘤中受体表达的模式变得失调。5-羟色胺受体,选择性5-羟色胺转运蛋白和5-羟色胺合成途径是潜在的化学治疗靶标,用于治疗治疗方法受限的几种癌症。通过一些常见问题,这项重要的小型回顾讨论了血清素参与人类癌症进展的相关性。与正常细胞或组织相比,特定受体亚型与肿瘤进展的不同基本阶段有关,并且在几种人类肿瘤中受体表达的模式变得失调。5-羟色胺受体,选择性5-羟色胺转运蛋白和5-羟色胺合成途径是潜在的化学治疗靶标,用于治疗治疗方法受限的几种癌症。通过一些常见问题,这项重要的小型回顾讨论了血清素参与人类癌症进展的相关性。选择性5-羟色胺转运蛋白和5-羟色胺合成途径是治疗方法受限的几种癌症的潜在化学治疗靶标。通过一些常见问题,这项重要的小型回顾讨论了血清素参与人类癌症进展的相关性。选择性5-羟色胺转运蛋白和5-羟色胺合成途径是治疗方法受限的几种癌症的潜在化学治疗靶标。通过一些常见问题,这项重要的小型回顾讨论了血清素参与人类癌症进展的相关性。

更新日期:2018-06-21
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