Today, the dramatic changes in types of food consumed have led to an increased burden of chronic diseases. Therefore, the emphasis of food research is not only to ensure quality food that can supply adequate nutrients to prevent nutrition related diseases, but also to ensure overall physical and mental-health. This has led to the concept of functional foods and nutraceuticals (FFNs), which can be ideally produced and delivered through plants. Metabolomics can help in getting the most relevant functional information, and thus has been considered the greatest –OMICS technology to date. However, metabolomics has not been exploited to the best potential in plant sciences. The technology can be leveraged to identify the health promoting compounds and metabolites that can be used for the development of FFNs. This article reviews (i) plant-based FFNs-related metabolites and their health benefits; (ii) use of different analytic platforms for targeted and non-targeted metabolite profiling along with experimental considerations; (iii) exploitation of metabolomics to develop FFNs in plants using various biotechnological tools; and (iv) potential use of metabolomics in plant breeding. We have also provided some insights into integration of metabolomics with latest genome editing tools for metabolic pathway regulation in plants.

中文翻译：

---

代谢组学辅助的生物技术干预措施，用于开发基于植物的功能性食品和营养保健品

如今，所食用食物种类的急剧变化导致慢性病负担增加。因此，食品研究的重点不仅是确保能够提供足够营养以预防营养相关疾病的优质食品，而且还要确保整体身心健康。这导致了功能性食品和营养品（FFN）的概念，可以理想地通过植物生产和运输这些功能性食品和营养品。代谢组学可以帮助获取最相关的功能信息，因此迄今为止被认为是最大的–OMICS技术。但是，代谢组学尚未在植物科学中得到最大利用。可以利用该技术来确定可用于开发FFN的健康促进化合物和代谢物。本文概述了（i）植物性FFNs相关代谢物及其健康益处；（ii）将不同的分析平台用于目标和非目标代谢物分析以及实验考虑；（iii）利用各种生物技术手段，利用代谢组学发展植物中的FFN；（iv）代谢组学在植物育种中的潜在用途。我们还提供了一些有关代谢组学与最新基因组编辑工具整合的见解，这些工具可用于植物代谢途径的调控。