The aim of this study was to determine the effects of n-3 ingestion on periodontal disease. Besides, we also investigated the relationship between plasma concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and/or aracdonic acid (AA), and periodontal disease. An electronic search was performed in several databases with the following keywords: “n-3,” DHA, EPA and polynsaturated fatty acids (PUFA) in combination with the term “periodontal disease” (PD). Only studies conducted with humans, involving clinical parameters of PD assessment and use of n-3 were selected, without restriction to the date of publication. The search has returned 1368 articles, 11 of which were selected. The results were separated according to the type of n-3 ingestion: supplementation or n-3 content in normal diet. In the studies where n-3 has been supplemented, there was no significant difference in the clinical severity of PD compared to the control subjects. However, in patients where levels of n-3 were evaluated in a usual diet, a lower disease severity was reported. We have detected a preventive effect related to plasma levels of EPA and DHA against PD progression. Thus, n-3 ingestion may beneficially interfere in PD progression, depending on the duration and dosage of consumption.

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n-3摄入可能会调节牙周疾病的严重程度？系统评价

这项研究的目的是确定n-3摄入对牙周疾病的影响。此外，我们还研究了二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和/或二十碳四烯酸（AA）的血浆浓度与牙周疾病之间的关系。在几个数据库中使用以下关键字进行了电子搜索：“ n-3”，DHA，EPA和多饱和脂肪酸（PUFA）结合术语“牙周疾病”（PD）。只选择与人类进行的涉及PD评估的临床参数和使用n-3的研究，而不受发布日期的限制。搜索返回了1368篇文章，其中11篇被选中。根据n-3摄入的类型（补充或正常饮食中n-3的含量）将结果分开。在补充了n-3的研究中，与对照组相比，PD的临床严重程度没有显着差异。但是，在按常规饮食评估n-3水平的患者中，据报道病情严重程度较低。我们已经检测到与EPA和DHA血浆水平有关的PD预防作用。因此，n-3摄入可能会有益地干扰PD的进展，具体取决于消耗的时间和剂量。