A series of unique C₃ symmetric tripodal receptors, A–E containing hexasubstituted aryl core decorated with an alternate array of coumarin-triazole moieties and methyl groups have been synthesized, characterized and investigated for fluoride ion recognition (tetrabutylammonium salt) in dimethyl sulphoxide (DMSO). A pleothora of spectroscopic studies (fluorescence, UV–vis, ¹H NMR and ¹⁹F NMR titrations) exhibits that out of the five derivatives synthesized, only one, receptor D displays selective five fold fluorescence enhancement with fluoride ion (TBA salt) at 480 nm wavelength over other anions at a detection limit of 2.6 × 10⁻⁵ M. Selectivity may be ascribed to strategical incorporation of trifluoromethyl group in the scaffold of receptor D which modulated the binding ability of the receptor, so that it is able to bind fluoride ion exclusively and selectively in preorganized C₃ symmetric cavity formed by its three arms. ¹H NMR and ¹⁹F NMR titration validate CH⋯F- hydrogen binding interactions via downfield shift of CH peak at δ 8.47 ppm by δ 0.5 ppm and upfield shift of peak at δ −102 ppm due to free fluoride ion 2.98 ppm, respectively. Further, HRMS study of receptor-fluoride complex gave evidence for the formation of 1:1 stoichiometric ratio between receptor and fluoride ion. Computations using density functional theory have shown that in 1:1 complex of receptor and fluoride ion, the three arms are directed in same orientation forming a cavity where it fits fluoride ion by CH⋯F- hydrogen binding interactions.

合成了一系列独特的C ₃对称三脚架受体，即含有六取代的芳基核心并饰有香豆素-三唑部分和甲基的交替排列的A–E，表征并研究了其在二甲基亚砜（DMSO）中的氟离子识别（四丁基铵盐）的特性。 ）。大量的光谱研究（荧光，UV-vis，¹ H NMR和¹⁹ F NMR滴定）显示，在合成的五种衍生物中，只有一种受体D在480处显示出氟化物离子（TBA盐）选择性的五倍荧光增强作用在2.6×10 ^-5的检出限下超过其他阴离子的nm波长M.选择性可能归因于三氟甲基在受体D支架中的战略性结合，从而调节了受体的结合能力，因此它能够在其三臂形成的预组织的C ₃对称腔中排他并选择性地结合氟离子。。¹ H NMR和¹⁹ F NMR滴定验证Ç ħ⋯F-氢结合相互作用通过的C低磁场移位处于H峰δ 8.47 ppm的δ 0.5ppm的和在峰的高磁场位移δ由于游离氟离子为2.98 ppm，因此分别为-102 ppm。此外，受体-氟化物络合物的HRMS研究为受体与氟离子之间化学计量比为1：1的形成提供了证据。使用密度泛函理论的计算表明，在受体与氟离子的1：1络合物中，三个臂以相同的方向定向，形成一个空腔，通过C H⋯F-氢键相互作用使其适合氟离子。