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Methyl dihydrojasmonate and lilial are the constituents with an "off-label" insect repellence in perfumes
PLOS ONE ( IF 3.7 ) Pub Date : 2018-06-19 , DOI: 10.1371/journal.pone.0199386
Fangfang Zeng , Pingxi Xu , Kaiming Tan , Paulo H. G. Zarbin , Walter S. Leal

Insect repellents are widely used to fend off nuisance mosquitoes and, more importantly, to reduce or eliminate mosquito bites in areas where viruses and other vector-borne diseases are circulating. Synthesized more than six decades ago, DEET is the most widely used insect repellent. Plant-derived compounds are used in a plethora of commercial formulations and natural recipes to repel mosquitoes. They are also used as fragrances. We analysed Bombshell® to identify the constituent(s) eliciting a previously reported “off- label” repellence activity. The two major fragrance ingredients in Bombshell, i.e., methyl dihydrojasmonate and lilial, demonstrated strong repellence against the southern house mosquito, Culex quinquefasciatus, in laboratory assays. Both compounds activated a previously identified DEET-sensitive odorant receptor, CquiOR136. These compounds were also major constituents of Ivanka Trump eau de parfum. The methyl dihydrojasmonate content was higher in the Ivanka Trump perfume than in Bombshell, the reverse being true for lilial. Both Bombshell and Ivanka Trump eaux de parfums retained activity for as long as 6 hours in laboratory assays. Although wearing these perfumes may repel nuisance mosquitoes, their use as “off-label” repellents against infected mosquitoes is not recommended.



中文翻译:

二氢茉莉酮酸甲酯和lilial是香水中具有“标签外”驱虫剂的成分

驱虫剂被广泛用于抵御令人讨厌的蚊子,更重要的是,在病毒和其他媒介传播的疾病正在传播的地区,减少或消除蚊子叮咬。DEET是六十多年前合成的,是使用最广泛的驱虫剂。植物来源的化合物被用于许多商业配方和天然配方中以驱除蚊子。它们也用作香料。我们分析了重磅炸弹®,以确定引发先前报道的“摘标签”排斥行为构成(一个或多个)。重磅炸弹中的两种主要香料成分,即二氢茉莉酮酸甲酯和Lilial,对南方家蝇蚊库克斯Culex quinquefasciatus)表现出强烈的排斥力,在实验室分析中。两种化合物均激活了先前确定的对DEET敏感的增味剂受体CquiOR136。这些化合物也是伊万卡·特朗普香水的主要成分。伊万卡·特朗普(Ivanka Trump)香水中的二氢茉莉酮酸甲酯含量高于炸弹(Bombshel​​l)中的含量,反之亦然。在实验室化验中,重磅炸弹和伊万卡·特朗普香水都保留了长达6个小时的活性。尽管戴着这些香水可以驱除令人讨厌的蚊子,但不建议将它们用作“不合格”的驱蚊剂来抵抗被感染的蚊子。

更新日期:2018-06-20
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