The efficient, 12–14 step (LLS) total synthesis of (−)‐halenaquinone has been achieved. Key steps in the synthetic sequence include: (a) proline sulfonamide‐catalyzed, Yamada–Otani reaction to establish the C6 all‐carbon quaternary stereocenter, (b) multiple, novel palladium‐mediated oxidative cyclizations to introduce the furan moiety, and (c) oxidative Bergman cyclization to form the final quinone ring.

中文翻译：

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（-）-哈兰醌的对映选择性合成

已经实现了（-）-卤代苯醌的高效12-14步（LLS）全合成。合成过程中的关键步骤包括：（a）脯氨酸磺酰胺催化的Yamada–Otani反应，以建立C6全碳四元立体中心，（b）多个新颖的钯介导的氧化环化反应，以引入呋喃部分，和（c ）氧化伯格曼环化反应形成最终的醌环。