Total synthesis of modified pentapeptide, caldoramide, a cytotoxic linear pentapeptide from the marine cyanobacterium Caldora penicillate is described. Notable features of the route include the efficient preparation of three key fragments and final assembly to the natural product via sequential amide couplings. The spectral data of the synthetic compound was found to be in comparison with that of the isolated natural product.

中文翻译：

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全合成修饰的五肽，钙酰胺

描述了从海洋蓝藻青霉（Caldora penicillate）的改性五肽，钙酰胺（一种细胞毒性的线性五肽）的全合成。该路线的显着特征包括有效制备三个关键片段，并通过顺序的酰胺偶联最终组装成天然产物。发现合成化合物的光谱数据与分离的天然产物的光谱数据相比较。