Berry consumption is associated with colorectal-cancer chemoprevention, but digestive conditions can affect this property. The bioaccessibility and apparent permeability coefficients of bioactive compounds from Andean Berry Juice (ABJ) after in vitro gastrointestinal digestion and colonic fermentation were analyzed. The antiproliferative effect of the fermented nondigestible fraction was evaluated against SW480 colon-adenocarcinoma cells. Gallic acid displayed the highest bioaccessibility in the mouth, stomach, small intestine, and colon. However, chlorogenic acid exhibited the highest apparent permeability coefficients (up to 1.98 × 10^–4 cm/s). The colonic-fermentation fraction showed an increase of ≥50% antiproliferative activity against SW480 cells (19.32%, v/v), equivalent to those of gallic acid (13.04 μg/g), chlorogenic acid (7.07 μg/g), caffeic acid (0.40 μg/g), ellagic acid (7.32 μg/g), rutin (6.50 μg/g), raffinose (0.14 mg/g), stachyose (0.70 mg/g), and xylose (9.41 mg/g). Bioactive compounds from ABJ are bioaccessible through the gastrointestinal tract and colon fermentation, resulting in antiproliferative activity.

中文翻译：

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安第斯浆果（Vaccinium meridionale Swartz）果汁的体外消化过程中的生物可及性和生物活性化合物的抗增殖作用

浆果的摄入与大肠癌的化学预防有关，但是消化条件会影响这种特性。分析了安第斯浆果果汁（ABJ）中的生物活性化合物在体外胃肠消化和结肠发酵后的生物可及性和表观渗透系数。评估了发酵的不易消化级分对SW480结肠腺癌细胞的抗增殖作用。没食子酸在口腔，胃，小肠和结肠中显示出最高的生物可及性。然而，绿原酸表现出最高的表观渗透系数（高达1.98×10 ^–4厘米/秒）。结肠发酵级分显示出对SW480细胞的抗增殖活性增加≥50％（19.32％，v / v），相当于没食子酸（13.04μg/ g），绿原酸（7.07μg/ g），咖啡酸（0.40μg/ g），鞣花酸（7.32μg/ g），芦丁（6.50μg/ g），棉子糖（0.14 mg / g），水苏糖（0.70 mg / g）和木糖（9.41 mg / g）。来自ABJ的生物活性化合物可通过胃肠道和结肠发酵而被生物利用，从而产生抗增殖活性。