The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.

中文翻译：

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抗葡萄球菌脂氨酸是核糖体合成的脂肽

从树型微细菌培养物中分离出的有效的抗菌肽肽微卵磷脂具有新的三氨基二羧酸部分，称为卵磷脂，并且具有空前的N末端胍基脂肪酸。我们确定了相应的生物合成基因簇，并在体外重构了avionin生物合成的中心步骤。基因组挖掘和从诺卡氏菌中分离出Nocavionin的结果表明，这种称为Lantlanthines的瘦肽肽的分布广泛，可能用作未来的抗菌药物。