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Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis
Neuroscience & Biobehavioral Reviews ( IF 8.2 ) Pub Date : 2018-06-18 , DOI: 10.1016/j.neubiorev.2018.06.015
Willem S. Eikelboom , Nikki Janssen , Lize C. Jiskoot , Esther van den Berg , Ardi Roelofs , Roy P.C. Kessels

Objective

The distinction between Primary Progressive Aphasia (PPA) variants remains challenging for clinicians, especially for the non-fluent (nfv-PPA) and the logopenic variants (lv-PPA). Previous research suggests that memory tests might aid this differentiation. This meta-analysis compares memory function among PPA variants.

Method

Effects sizes were extracted from 41 studies (N = 849). Random-effects models were used to compare performance on episodic and working memory tests among PPA patients and healthy controls, and between the PPA variants.

Results

Memory deficits were frequently observed in PPA compared to controls, with large effect sizes for lv-PPA (Hedges’ g = −2.04 [−2.58 to −1.49]), nfv-PPA (Hedges’ g = −1.26 ([−1.60 to −0.92], p < .001)), and the semantic variant (sv-PPA; Hedges’ g = −1.23 [−1.50 to −0.97]). Sv-PPA showed primarily verbal memory deficits, whereas lv-PPA showed worse performance than nfv-PPA on both verbal and non-verbal memory tests.

Conclusions

Memory deficits were more pronounced in lv-PPA compared to nfv-PPA. This suggests that memory tests may be helpful to distinguish between these PPA variants.



中文翻译:

原发性进行性失语症的发作和工作记忆功能:一项荟萃分析

客观的

对于临床医生而言,原发进行性失语症(PPA)变体之间的区别仍然具有挑战性,尤其是对于非流利性(nfv-PPA)和低渗性变体(lv-PPA)。先前的研究表明,记忆力测试可能有助于这种分化。这项荟萃分析比较了PPA变体之间的记忆功能。

方法

效应量是从41项研究中提取的(N  = 849)。随机效应模型用于比较PPA患者和健康对照以及PPA变体之间的情景和工作记忆测试表现。

结果

记忆缺陷在PPA中常常观测到与对照组相比,具有大的效果尺寸LV-PPA(树篱= -2.04 [-2.58至-1.49]),NFV-PPA(树篱= -1.26([-1.60至-0.92],p  <0.001)),并且所述语义变体(SV-PPA;树篱= -1.23 [-1.50至-0.97])。Sv-PPA主要表现为口头记忆缺陷,而lv-PPA在口头和非语言记忆测试中的表现都比nfv-PPA差。

结论

与nfv-PPA相比,lv-PPA中的记忆缺陷更为明显。这表明记忆力测试可能有助于区分这些PPA变体。

更新日期:2018-06-18
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