A series of polysubstituted pyrrolo[3,2-d]pyrimidinedione derivatives have been synthesized in excellent yields. This prominent scaffold is obtained via an Al(OTf)₃-catalyzed tandem addition-annulation sequence between propargylic alcohols and aminopyrimidines. The process is simple, facile, inexpensive, and provides a diverse range of substituted pyrrolo [3,2-d]pyrimidinedione derivatives with short reaction times from readily obtainable starting materials.

中文翻译：

---

Al（OTf）₃催化一锅合成吡咯并[3,2- d ]嘧啶二酮衍生物

已经以优异的产率合成了一系列多取代的吡咯并[3，2- d ]嘧啶二酮衍生物。该突出的支架是通过在炔丙醇和氨基嘧啶之间的Al（OTf）₃催化的串联加成-加环序列获得的。该方法简单，容易，廉价，并提供了从容易获得的起始原料起反应时间短的多种取代的吡咯并[3，2- d ]嘧啶二酮衍生物。