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Jaboticaba extract prevents prediabetes and liver steatosis in high-fat-fed aging mice
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-06-15 , DOI: 10.1016/j.jff.2018.06.005
C.A. Lamas , S.A. Lenquiste , A.M. Baseggio , L. Cuquetto-Leite , L.A. Kido , A.C. Aguiar , M.N. Erbelin , C.B. Collares-Buzato , M.R. Maróstica , V.H.A. Cagnon

We developed a patented jaboticaba peel extract (PJE) aiming to investigate PJE dose-dependent effect in liver and metabolism of high-fat-fed aging mice. Male FVB mice were distributed as follows: YG(young; 3-months-old), AG(aged; 11-months-old), HfAG(aged + high-fat diet), JAGI(aged + 2.9gPJE/Kg), JAGII(aged + 5.8gPJE/Kg), HfJAGI(aged + high-fat diet + 2.9gPJE/Kg) and HfJAGII(aged + high-fat diet + 5.8gPJE/Kg). PJE showed a potent antioxidant activity and high bioactive compounds content. Both PJE doses prevented weight gain, dyslipidemia, hyperglycemia, reduced COX-2 level and improved HDL-cholesterol, pIRS-1, and PPARγ levels in high-fat-fed aging mice. Only HfJAGII showed lower TNFα level, insulin resistance, and glucose intolerance relative to HfAG. Taking aging into consideration, PJE prevented dyslipidemia and hyperglycemia, reduced TNFα besides increasing pIRS-1 and PPARγ levels, and restoring the hepatic structure in aged mice. Thus, PJE anti-inflammatory, hypoglycemic and lipid modulation capacity prevented the pre-diabetes and NAFLD in this model, being indicated as potential therapy to prevent hepatic and metabolic disorders associated to obesity, diabetes, and aging.



中文翻译:

Jaboticaba提取物可预防高脂喂养衰老小鼠的前驱糖尿病和肝脂肪变性

我们开发了获得专利的虎皮果提取物(PJE),旨在研究PJE在高脂喂养衰老小鼠的肝脏和代谢中的剂量依赖性效应。雄性FVB小鼠的分布如下:YG(年轻; 3个月大),AG(年龄; 11个月大),HfAG(年龄+高脂饮食),JAGI(年龄+ 2.9gPJE / Kg), JAGII(年龄+ 5.8gPJE / Kg),HfJAGI(年龄+高脂饮食+ 2.9gPJE / Kg)和HfJAGII(年龄+高脂饮食+ 5.8gPJE / Kg)。PJE显示出有效的抗氧化活性和高生物活性化合物含量。两种PJE剂量均可防止高脂喂养衰老小鼠的体重增加,血脂异常,高血糖,降低COX-2水平并改善HDL-胆固醇,pIRS-1和PPARγ水平。相对于HfAG,只有HfJAGII表现出较低的TNFα水平,胰岛素抵抗和葡萄糖耐受不良。考虑到衰老,PJE可预防血脂异常和高血糖症,除了增加pIRS-1和PPARγ水平,并降低衰老小鼠的肝结构外,还可以降低TNFα。因此,在该模型中,PJE的抗炎,降血糖和脂质调节能力可预防糖尿病前期和NAFLD,被认为是预防与肥胖,糖尿病和衰老相关的肝脏和代谢疾病的潜在疗法。

更新日期:2018-06-15
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