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Cytotoxic and anti-inflammatory active phloroglucinol derivatives from Rhodomyrtus tomentosa
Phytochemistry ( IF 3.8 ) Pub Date : 2018-09-01 , DOI: 10.1016/j.phytochem.2018.05.018
Yu-Bo Zhang , Wen Li , Lin Jiang , Li Yang , Neng-Hua Chen , Zhong-Nan Wu , Yao-Lan Li , Guo-Cai Wang

Seven undescribed phloroglucinol derivatives, tomentodiones N-T, and eleven known ones were isolated from Rhodomyrtus tomentosa. Tomentodione N is the first example of a β-triketone unit coupled with an isoamyl alcohol through a furan fused-ring, and tomentodiones N, S, T were three racemates. The undescribed structures were elucidated by means of spectroscopic, X-ray diffraction, electronic circular dichroism calculation, and chemical methods. In addition, the isolated compounds were determined for the cytotoxic activities on HeLa cells and anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.

中文翻译:

来自毛桃木的细胞毒性和抗炎活性间苯三酚衍生物

七种未描述的间苯三酚衍生物、绒毛二酮 NT 和十一种已知的从毛茸茸中分离出来。Tomentodione N 是 β-三酮单元通过呋喃稠环与异戊醇偶联的第一个例子,tomentodiones N、S、T 是三个外消旋物。通过光谱、X 射线衍射、电子圆二色性计算和化学方法阐明了未描述的结构。此外,还测定了分离的化合物对 HeLa 细胞的细胞毒活性和 LPS 刺激的 RAW 264.7 细胞的抗炎活性。
更新日期:2018-09-01
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