The role of metal ions in virus-host interactions is largely unknown. In the present computational study, the putative zinc, manganese, magnesium, and iron metalloproteomes of 226 different viruses were identified and then the human proteins interacting the viral metalloproteomes were retrieved through network-based bioinformatics. Protein features such as abundance, function and structurally disorder were classified according to the metal type bound to viral proteins. Likely perturbations of host cellular metal homeostasis by viral metal binders are also discussed. Furthermore, possible molecular linkage between the human proteome infected by viral metalloproteins with twelve neurological disorders was examined by in silico gene network analysis.

金属离子在病毒-宿主相互作用中的作用在很大程度上尚不清楚。在本计算研究中，鉴定了226种不同病毒的假定的锌，锰，镁和铁金属蛋白质组，然后通过基于网络的生物信息学检索了与病毒金属蛋白质组相互作用的人类蛋白质。根据与病毒蛋白质结合的金属类型，对蛋白质特征（例如丰度，功能和结构紊乱）进行分类。还讨论了病毒金属结合剂对宿主细胞金属稳态的可能扰动。此外，通过计算机基因网络分析检查了被病毒金属蛋白感染的具有十二种神经系统疾病的人类蛋白质组之间的可能的分子连接。