Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as examples.

中文翻译：

---

生物药物半衰期延长的化学策略：脂化作用及其替代方法

新生物药物的设计通常需要延长半衰期的策略。该观点的重点是通过白蛋白结合或通过自组装形成更大结构的过程，从而传递持久的化学部分，以GLP-1和胰岛素为例。