The last couple of decades have witnessed tremendous development within N‐heterocyclic carbene (NHC) organocatalysis. NHCs have been used as powerful organic catalysts in asymmetric synthesis. Although great achievements have been made in asymmetric NHC catalysis, their applications in kinetic resolution (KR), dynamic kinetic resolution (DKR), and desymmetrization processes have been relatively less developed. Moreover, limited activation modes have been involved in these processes. This review provides an overview of the NHC‐organocatalyzed KR, DKR, and desymmetrization reactions in the preparation of chiral functional molecules. The aim is to highlight both the importance and elegance of these methods in the construction of challenging chiral compounds and to provide our own perspective on future development in this direction.

中文翻译：

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N-杂环碳烯（NHC）-有机催化的动力学拆分，动态动力学拆分和不对称化

在过去的几十年中，N杂环卡宾（NHC）有机催化技术取得了长足的发展。NHC已在不对称合成中用作强大的有机催化剂。尽管在不对称NHC催化方面取得了巨大成就，但它们在动力学拆分（KR），动态动力学拆分（DKR）和去对称化过程中的应用却相对较少。而且，在这些过程中涉及有限的激活模式。这篇综述概述了NHC有机催化的KR，DKR和去对称化反应在制备手性功能分子中的作用。目的是强调这些方法在构建具有挑战性的手性化合物中的重要性和优雅性，并就此方向的未来发展提供我们自己的观点。