Cu(I) salts have been shown to improve the regioselectivity and rate of the Ru-catalyzed alkyne–azide click reaction of internal alkynes with azides. While Cu and Ru individually provide complementary regioselectivity in the case of terminal alkynes, the synergistic effect of these two species in situ significantly improves regiochemical outcomes in the case of internal alkynes. The substrate scope of these new reaction conditions is also reported.

中文翻译：

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铜和钌对内部炔烃炔-叠氮化Click点击反应中区域选择性的协同作用

铜（I）盐已显示可提高内部炔烃与叠氮化物的Ru催化的炔烃-叠氮化物点击反应的区域选择性和反应速率。在末端炔烃的情况下，Cu和Ru分别提供互补的区域选择性，而在内部炔烃的情况下，这两种物质的协同作用显着改善了区域化学结果。还报道了这些新反应条件的底物范围。