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Geometry‐Constrained Iminopyridyl Palladium‐Catalyzed Hydroarylation of Alkynes to Prepare Tri‐substituted Alkenes Using Alcohol as Reductant
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2018-07-02 , DOI: 10.1002/adsc.201800423
Ke Wu 1 , Nan Sun 1 , Baoxiang Hu 1 , Zhenlu Shen 1 , Liqun Jin 1, 2 , Xinquan Hu 1, 2
Affiliation  

We developed an efficient and straightforward method to prepare tri‐substituted alkenes through palladium‐catalyzed hydroarylation of alkynes with aryl bromides. Diarylacetylenes and alkyl(aryl)acetylenes could be well hydroarylated with various aryl bromides in moderate to excellent yields. Mechanistic studies suggested that alcohol was the reductant to provide hydride through β‐H elimination. Gram scale reaction further demonstrated the practicality and efficiency of the newly developed strategy.

中文翻译:

几何约束的氨基吡啶钯催化的炔烃加氢芳基化反应,以醇为还原剂制备三取代的烯烃

我们开发了一种有效且直接的方法,通过钯与芳基溴化物催化炔烃的加氢芳基化反应来制备三取代烯烃。二芳基乙炔和烷基(芳基)乙炔可以用各种芳基溴化物以中等至极好的收率很好地进行氢芳基化。机理研究表明,酒精是通过消除β-H来提供氢化物的还原剂。革兰氏反应进一步证明了新开发策略的实用性和有效性。
更新日期:2018-07-02
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