Some medications and herbal drugs are suggested to ameliorate impaired plasma glucose and its complications in pre-diabetic patients. This study aimed to assess the effect of cumin essential oil supplementation on metabolic markers and serum leptin in pre-diabetic subjects. In a double-blind randomized controlled trial, subjects of intervention group received one cumin soft gel (containing 75 mg of cumin essential oil) per day for 10 weeks, while subjects of control group received one placebo soft gel. Glycemic indices and serum leptin did not significantly improve in intervention group. Except serum total cholesterol, other markers of lipid profile as well as anthropometric indexes improved in intervention group. Subgroup analyses represented that lipid profile and anthropometric indexes were ameliorated in women after intervention, while did not show significant improvement in men. It can be concluded that cumin essential oil can be used as an adjuvant therapy to ameliorate metabolic status in pre-diabetics.

建议使用某些药物和草药来改善糖尿病前期患者血浆葡萄糖受损及其并发症。这项研究旨在评估补充孜然精油对糖尿病前期受试者代谢指标和血清瘦素的影响。在一项双盲随机对照试验中，干预组的受试者每天接受一种孜然软凝胶（含75 mg孜然精油），持续10周，而对照组的受试者则接受一种安慰剂软凝胶。干预组血糖指数和血清瘦素水平无明显改善。除血清总胆固醇外，干预组的其他血脂指标和人体测量指标均得到改善。亚组分析表明，干预后女性的脂质分布和人体测量指标得到改善，而男性则没有表现出明显的改善。可以得出结论，孜然精油可用作改善糖尿病前期代谢状况的辅助疗法。